Associate Professor
Assoc. Dean Academic Affairs
debasmitaniser.ac.in
+91-674-2494204
Cellular and Molecular Genetics of Aging disorders
Kapuganti RS, Alone DP. Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma. Mol Aspects Med. 2023 Sep 18;94:101214.
Kapuganti RS, Sahoo L, Mohanty PP, Hayat B, Parija S, Alone DP. Role of clusterin gene 3'-UTR polymorphisms and promoter hypomethylation in the pathogenesis of pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Biochim Biophys Acta Gene Regul Mech. 2023 Aug 29;1866(4):194980.
Kapuganti RS, Hayat B, Padhy B, Mohanty PP, Alone DP. Dickkopf-1 and ROCK2 upregulation and associated protein aggregation in pseudoexfoliation syndrome and glaucoma. Life Sci. 2023 May 20:121797.
Padhy B, Kapuganti RS, Hayat B, Mohanty PP, Alone DP. Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression. Gene. 2023 Feb 20; 854:147096.
Chakraborty M, Jandhyam H, Basak SK, Das S, Alone DP. Intergenic variants, rs1200114 and rs1200108 are genetically associated along with a decreased ATP1B1 expression in Fuchs Endothelial Corneal Dystrophy. Experimental Eye Research. 2023 Mar; 228:109403.
Kapuganti RS, Bharati B, Mohanty PP, Alone DP. Genetic variants and haplotypes in fibulin-5 (FBLN5) are associated with pseudoexfoliation glaucoma but not with pseudoexfoliation syndrome. Bioscience Reports. 2023 Mar 31; 43(3): BSR20221622.
Ramani Shyam Kapuganti, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Quantitative analysis of circulating levels of vimentin, clusterin and fibulin-5 in patients with pseudoexfoliation syndrome and glaucoma. Experimental Eye Research. 2022 Nov; 224:109236.
Maynak Chakraborty, Rajesh Kumar Das, Sujata Samal, Sujata Das, Debasmita Pankaj Alone. Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B. Gene. 2022 Apr 5; 817:146179.
Biswajit Padhy and Debasmita Pankaj Alone. Is pseudoexfoliation glaucoma a neurodegenerative disorder? J Biosciences, 2021, 46:97
Rakesh Mishra, Rohit Kunar, Lolitika Mandal, Debasmita Pankaj Alone, Shanti Chandrasekharan, Anand Kumar Tiwari, Madhu Gwaldas Tapadia, Asim Mukherjee, Jagat Kumar Roy. A forward genetic approach to mapping a P-Element second site mutation identifies DCP2 as a novel tumor suppressor in Drosophila melanogaster.G3: Genes, Genomes, Genetics, 2020, 10 (8): 2601-2618.
Bushra Hayat, Ramani Shyam Kapuganti, Biswajit Padhy, Pranjya Paramita Mohanty & Debasmita Pankaj Alone. Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma. Journal of Human Genetics, 2020, doi: 10.1038/s10038-020-0736-8.
Padhy B, Kapuganti RS, Hayat B, Mohanty PP, Alone DP. De novo variants in an extracellular matrix protein coding gene, fibulin-5 (FBLN5) are associated with pseudoexfoliation. European Journal of Human Genetics, 2019, doi: 10.1038/s41431-019-0482-6.
Gargi Gouranga Nanda and Debasmita Pankaj Alone. REVIEW: Current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy. Molecular Vision, 2019, 25: 295-310.
Bushra Hayat, Biswajit Padhy, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis. Experimental Eye Research, 2019, 181: 197-207.
Gargi Gouranga Nanda, Malloji Vinay Kumar, Laxmipriya Pradhan, Biswajit Padhy, Satabdi Sundaray, Sujata Das, Debasmita Pankaj Alone. rs4246215 is targeted by hsa-miR1236 to regulate FEN1 expression but is not associated with Fuchs' endothelial corneal dystrophy. PLOS ONE, 2018, 13 (9): e0204278
Biswajit Padhy, Bushra Hayat, Gargi Gouranga Nanda, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Pseudoexfoliation and Alzheimer's associated CLU risk variant, rs2279590 lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression. Human Molecular Genetics, 2017, Volume 26, Issue 22, 15 November 2017, Pages 4519–4529
Phom Limamanen, Achumi Bovita, Alone Debasmita P, Muralidhara M, Yenisetti S C. Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease is Phase Specific: Implication of its Therapeutic Effectiveness. Rejuvenation Res., 2014, 17 (6): 481-9.
Nanda Gargi G, Padhy Biswajit, Samal Sujata, Das Sujata, Alone Debasmita P. Genetic association of TCF4 intronic polymorphisms, CTG18.1 and rs17089887, with Fuchs' endothelial corneal dystrophy in an Indian population. Investigative Ophthalmology & Visual Science, 2014, 55 (11):7674-80.
Padhy Biswajit, Nanda Gargi G, Chowdhury Mahesweta, Padhi Debanand, Rao Aparna, Alone Debasmita P. Role of an extracellular chaperone, clusterin in the pathogenesis of pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Experimental Eye Research, 2014, 127: 69-76.
Das Sourajit S, Nanda Gargi G, Alone Debasmita P. Artemisinin and Curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity. IUBMB Life, 2014 66: 496-506.
Alone Debasmita P, Rodriguez Jason C, Noland Cameron L and Nash Howard A. Impact of copy number variation on Anesthesia in Drosophila melanogaster. Anesthesiology, 2009, 111, 15-24
Tiwari Anand K, Alone Debasmita P and Roy Jagat K. Rab11 is essential for fertility in Drosophila. Cell Biology International, 2008, 32, 1158-1168.
Alone Debasmita P, Scott Robert L and Nash Howard A. An Ion Channel that Influences Anesthesia Sensitivity: Designing a Genetic Test for Assessing a Candidate Anesthetic Target. Int. Congress Series, 2005, 1283, 119-125.
Alone Debasmita P, Tiwari Anand K, Mandal Lolitika, Li Mingfa, Mechler Bernard M and Roy Jagat K. Rab11 is required during Drosophila eye development. Int. J Dev Biol. 2005, 49, 873-879.
With the shifting demographics towards older age, there is a major concern for age-related disorders. 90% of individuals dying each year are due to age-related causes. Understanding the genome, epigenome and proteome between healthy and diseased state of these individuals pave a way for unravelling bio-markers for early diagnosis and/or therapeutics for various diseases. Our goal is to find these underlying players that change the micro-environmental niche differently in a diseased state during the developmental process of aging and hence are responsible for these age related-disorders. We are currently focusing on understanding the pathomechanism of two neurodegenerative eye disorders (Glaucoma, the leading cause of irreversible World Blindness and Corneal Endothelial Dystrophies) as well as Cancer using a pleothora of cellular, biochemical, genetics, genomics and molecular biology techniques involving human samples, Drosophila models as well as in vitro cell lines.
