NISER

• B. Sc Chemistry (Erode Arts College, Erode, Affiliated to Bharathiar University, Coimbatore, India)
• M. Sc Chemistry (R K M Vivekananda College, Chennai, Affiliated to University of Madras, Chennai, India)
• Ph. D (with Prof. H. Ila, Indian Institute of Technology Kanpur, India)
• AvH Fellow (with Prof. Christoph Schneider, University of Leipzig, Germany)

Synthetic Organic Chemistry with specialization in heterocyclic chemistry and catalytic organic transformations.

AvH Fellow 2007-2008

After Joining NISER

2025

1. PIFA-Mediated Intramolecular Dearomatization of Phenol-Tethered 1,2-Diazoles: Synthesis of Spirocyclohexadienone Pyrazolo[3,4-b]piperidinones, P. Natarajan, P. Bachhaley, S. Tripathy, P. A. Vasantharaj, and S. Peruncheralathan, Synthesis, 2025, 57, 425–440. (Invited Article)
2. Palladium-Catalyzed Domino Heteroarylation of Thioamides: A Simple Route to Benzothieno[2,3-b]quinolones, M. Janni, A. Thirupathi, S. V. Subramaniam, and S. Peruncheralathan, Synthesis, 2025, 57, 229–239. (Invited Article)

2024

1. KOH-Mediated Synthesis of Substituted Isothiazoles via Two-Component Annulation with Dithioates and Arylacetonitriles, S. K. Meher, V. R. Velpuri, S. R. Naikwade, S. Peruncheralathan, and K. Venkatasubbaiah, J. Org. Chem., 2024, 89, 12785–12789.
2. Novel Organosulfur Building Blocks for Heterocycle Synthesis, S. Peruncheralathan and H. Ila, Synlett, 2024, 35, 2251–2272.
3. PIFA-Mediated Intramolecular N-Arylation of 2-Aminoquinoxalines to Afford Indolo[2,3-b]quinoxaline Derivatives, S. V. Subramaniam, B. Singh, P. Natarajan, and S. Peruncheralathan, Org. Biomol. Chem., 2024, 22, 5803–5808.
4. Organocatalytic Dearomatization of 5-Aminopyrazoles: Synthesis of 4-Hydroxypyrazolines, P. Natarajan, S. V. Subramaniam, and S. Peruncheralathan, J. Org. Chem., 2024, 89, 10258–10271.
5. Unexpected Dearomatization of N-Protected 5-Aminopyrazoles at Ambient Temperature: A Simple Route to Highly Functionalized Pyrazolines, P. Natarajan, A. Chatterjee, S. J. Siddharth, and S. Peruncheralathan, Org. Biomol. Chem., 2024, 22, 6288–6293.
6. Organocatalytic Chemoselective C4-Benzylation of 5-Aminopyrazoles, P. Natarajan, S. Kanchithalaivan, A. Chatterjee, and S. Peruncheralathan, Asian J. Org. Chem., 2024, e202300628.
7. Nickel-Catalyzed Selective Arylation of Geminal Dinitriles: Direct Access to α-Cyano Carbonyl Compounds, A. Bhattacharya, S. V. Subramaniam, N. K. Kandukuri, and S. Peruncheralathan, J. Org. Chem., 2024, 89, 2571–2581.

2023

1. Nickel-Catalyzed Domino Reaction of α-Aryloxyacetonitriles with Arylboronic Acids: Synthesis of 2-Aroylbenzo[b]furans, S. V. Subramaniam, V. K. Dharmalingam, A. Bhattacharya, and S. Peruncheralathan, Org. Lett., 2023, 25, 8225–8229.
2. Synthesis, Structural, and Photophysical Properties of Pyrazolyl Bis(pentafluorophenyl)boron Complexes, A. C. Murali, P. Pratakshya, P. Patel, P. Nayak, S. Peruncheralathan, and K. Venkatasubbaiah, New J. Chem., 2023, 47, 17835–17842.
3. Cu(OTf)₂-Enhanced Intramolecular Nucleophilic N-Arylation of 2-Amino-3-Arylquinolines, A. Bhattacharya, N. R. Babu, D. Bandyopadhyay, and S. Peruncheralathan, J. Org. Chem., 2023, 88, 8843–8853.

2022

1. Hydrothermal Treatment as a Means of Improving the Solubility and Enhancing the diaCEST MRI Contrast Efficiency, S. Pandey, A. C. Keerthana, S. Madhulika, P. Prasad, S. Peruncheralathan, and A. Ghosh, New J. Chem., 2022, 46, 14888–14893.
2. The Role of Hydrogen Bonding in Tuning CEST Contrast Efficiency: A Comparative Study of Intra- and Intermolecular Hydrogen Bonding, S. Pandey, S. Chakraborty, R. Ghosh, D. Radhakrishnan, S. Peruncheralathan, and A. Ghosh, New J. Chem., 2022, 46, 1260–1266.
3. 2,3-Difunctionalized Benzo[b]thiophene Scaffolds Possessing Potent Antiangiogenic Properties, H. Singh, A. Thirupathi, B. Das, M. Janni, R. Kumari, S. Singh, M. Rashid, M. Wahajuddin, M. M. Balamurali, K. Jagavelu, and S. Peruncheralathan, J. Med. Chem., 2022, 65, 120–135.

2022

1. Metal-Free Ring Opening of 5-Amino-1,4-Diaryl-1H-pyrazoles: A Facile Access to 2-Aryl-3-Arylazoacrylonitriles, A. Chatterjee, D. Radhakrishnan, D. Bandyopadhyay, S. Kanchithalaivan, and S. Peruncheralathan, J. Heterocycl. Chem., 2022, 59, 1016–1024.

2021

1. Chemoselective Ullmann Reaction of α-Trisubstituted Thioamides: Synthesis of Novel 2-Iminobenzothiolanes, A. Bhattacharya, A. Thirupathi, P. Natarajan, and S. Peruncheralathan, ACS Omega, 2021, 6, 21169–21180.
2. Triflic Acid-Mediated N-Heteroannulation of β-Anilino-β-(methylthio)acrylonitriles: A Facile Synthesis of 4-Amino-2-(methylthio)quinolines, D. Bandyopadhyay, A. Thirupathi, D. Radhakrishnan, A. Panigrahi, and S. Peruncheralathan, Org. Biomol. Chem., 2021, 19, 8544–8553.
3. Paracetamol and Other Acetanilide Analogs as Intermolecular Hydrogen Bonding-Assisted Diamagnetic CEST MRI Contrast Agents, S. Chakraborty, S. Peruncheralathan, and A. Ghosh, RSC Adv., 2021, 11, 6526–6534.

2020

1. PtCl₂-Mediated Peripheral Transformation of Carbatriphyrin(3.1.1) into a Meso-Fused β,β′-Dimer and Its Monomer Analogue, M. Murugavel, B. Adinarayana, M. Das, S. Peruncheralathan, N. R. Palepu, and A. Srinivasan, Chem. Commun., 2020, 56, 12809–12812.
2. Copper-Catalyzed N-Arylation of 5-Aminopyrazoles: A Simple Route to Pyrazolo[3,4-b]indoles, A. Chatterjee, C. Murmu, and S. Peruncheralathan, Org. Biomol. Chem., 2020, 18, 6571–6581.

2019

1. Core-Modified 48π and 42π Decaphyrins: Syntheses, Properties and Structures, A. Ghosh, S. Dash, A. Srinivasan, C. H. Suresh, S. Peruncheralathan, and T. K. Chandrashekar, Org. Chem. Front., 2019, 6, 3746–3753.

2018

1. Copper-Catalyzed Intramolecular N-Arylation of Ketene Aminals at Room Temperature: Synthesis of 2-Amino-3-Cyanoindoles, A. Thirupathi, M. Janni, and S. Peruncheralathan, J. Org. Chem., 2018, 83, 8668–8678.
2. Nickel-Catalyzed Site-Selective C–H Functionalization of α-Aryl Thioamides, D. Bandyopadhyay, A. Thirupathi, N. M. Dhage, N. Mohanta, and S. Peruncheralathan, Org. Biomol. Chem., 2018, 16, 6405–6409.

2017

1. Chemoselective Ullmann Coupling at Room Temperature: A Facile Access to 2-Aminobenzo[b]thiophenes, M. Janni, A. Thirupathi, S. Arora, and S. Peruncheralathan, Chem. Commun., 2017, 53, 8439–8442.

2016

1. Catalytic Selective Deuteration of Halo(hetero)arenes, M. Janni and S. Peruncheralathan, Org. Biomol. Chem., 2016, 14, 3091–3097.
2. Double Heteroannulation of S,N-Acetals: A Facile Access to Quinolone Derivatives, M. Janni, S. Arora, and S. Peruncheralathan, Org. Biomol. Chem., 2016, 14, 8781–8788.

2015

1. Tetraaryl Pyrazole Polymers: Versatile Synthesis, Aggregation-Induced Emission Enhancement and Detection of Explosives, V. Mukundam, A. Kumar, K. Dhanunjayarao, A. Ravi, S. Peruncheralathan, and K. Venkatasubbaiah, Polym. Chem., 2015, 6, 7764–7770.
2. AIEE Phenomenon: Tetraaryl vs. Triaryl Pyrazoles, S. Mukherjee, P. P. Salini, A. Srinivasan, and S. Peruncheralathan, Chem. Commun., 2015, 51, 17148–17151.

2012

1. Trideuteriomethoxylation of Aryl and Heteroaryl Halides, P. Dash, M. Janni, and S. Peruncheralathan, Eur. J. Org. Chem., 2012, 4914–4917.

Before Joining NISER

Postdoctoral Research

1. The Ti-BINOLate-Catalyzed, Enantioselective Ring Opening of meso-Aziridines with Amines, S. Peruncheralathan, S. Aurich, H. Teller, and C. Schneider, Org. Biomol. Chem., 2013, 11, 2787–2803.
2. Cationic Late-Transition-Metal Complexes Catalyze the Ring Opening of Aziridines with Amines, A. Marti, S. Peruncheralathan, and C. Schneider, Synthesis, 2012, 44, 27–36.
3. Titanium BINOLate-Catalyzed Aminolysis of meso-Aziridines: A Highly Enantioselective and Direct Access to 1,2-Diamines, S. Peruncheralathan, H. Teller, and C. Schneider, Angew. Chem. Int. Ed., 2009, 48, 4849–4852.
4. Indium(III) Chloride-Catalyzed Thiolysis of meso-Aziridines, S. Peruncheralathan, M. Henze, and C. Schneider, Tetrahedron Lett., 2007, 48, 6743–6746.
5. Scandium Triflate-Catalyzed Aminolysis of meso-Aziridines, S. Peruncheralathan, M. Henze, and C. Schneider, Synlett, 2007, 2289–2291.

Ph.D.

1. A New One-Pot, Three-Component Synthesis of 2,3,5-Substituted or Annulated 6-(Methylthio)pyridines, A. K. Yadav, S. K. S. Yadav, I. Siddiqui, S. Peruncheralathan, H. Ila, and H. Junjappa, Synlett, 2008, 2674–2680.
2. A Novel Anionic Domino Process for the Synthesis of o-Cyanoaryl Methylthio/Alkyl/Aryl/Heteroaryl Acetylenes, S. Kumar, S. Peruncheralathan, H. Ila, and H. Junjappa, Org. Lett., 2008, 10, 965–968.
3. Domino Carbocationic Rearrangement of α-[Bis(methylthio)methylene]alkyl-2-(3/2-Indolyl)cyclopropyl Ketones, A. K. Yadav, S. Peruncheralathan, H. Ila, and H. Junjappa, J. Org. Chem., 2007, 72, 1388–1394.
4. Highly Regioselective Synthesis of 1-Aryl-3 (or 5)-Alkyl/Aryl-5 (or 3)-(N-Cycloamino)pyrazoles, S. Peruncheralathan, A. K. Yadav, H. Ila, and H. Junjappa, J. Org. Chem., 2005, 70, 9644–9647.
5. Regioselective Synthesis of 1-Aryl-3,4-Substituted/Annulated-5-(Methylthio)pyrazoles and 1-Aryl-3-(Methylthio)-4,5-Substituted/Annulated Pyrazoles, S. Peruncheralathan, T. A. Khan, H. Ila, and H. Junjappa, J. Org. Chem., 2005, 70, 10030–10035.
6. Domino Carbocationic Rearrangements of α-[Bis(methylthio)methylene]alkyl-2-(Heteroaryl)cyclopropyl Ketones, S. Peruncheralathan, V. Sriram, H. Ila, and H. Junjappa, Tetrahedron, 2004, 60, 5603–5612.
7. α-Oxoketene Dithioacetals-Mediated Heteroaromatic Annulation Protocol for Benzoheterocycles: An Efficient Regiocontrolled Synthesis of Highly Substituted and Annulated Indazoles, S. Peruncheralathan, T. A. Khan, H. Ila, and H. Junjappa, Tetrahedron, 2004, 60, 3457–3464.
8. S,S-Dimethyl Dithiocarbonate: A Useful Reagent for Efficient Conversion of Aldoximes to Nitriles, T. A. Khan, S. Peruncheralathan, H. Ila, and H. Junjappa, Synlett, 2004, 2019–2021.
9. Domino Carbocationic Rearrangement of α-[Bis(methylthio)methylene]alkyl-2-Arylcyclopropyl Carbinols: Facile Access to 1-Arylindanes, P. K. Mohanta, S. Peruncheralathan, H. Ila, and H. Junjappa, J. Org. Chem., 2001, 66, 1503–1508.

Book Chapters

1. Domino Reactions Initiated by Nucleophilic Substitution, H. Ila, A. Acharya, and S. Peruncheralathan, in Domino Reactions: Concepts for Efficient Organic Synthesis, L. F. Tietze, Ed.; Wiley-VCH Verlag GmbH & Co. KGaA, 2014, pp. 105–140.
2. Industrial Application of Bond Functionalization Chemistry, P. K. Jat and S. Peruncheralathan, in Sustainable Approaches for Catalytic Bond Functionalization, D. Maiti and S. Rej, Eds.; Wiley-VCH, 2026, in press.

• Our research focuses on developing efficient and sustainable synthetic methods for biologically relevant molecules and functional heterocycles. Key areas include transition-metal catalysis, domino and cascade reactions, skeletal editing, organocatalysis, hypervalent iodine chemistry, C–H functionalization, cross-coupling, and organosulfur chemistry.
• We are particularly interested in the synthesis of benzo[b]thiophenes, benzo[b]furans, indoles, quinolines, pyrazoles, and related fused heterocycles. Our work also extends to medicinal chemistry, neuroprotective and antiangiogenic small molecules, functional carbohydrates, resistant starch, and microbiome-targeted approaches for neurodegenerative disorders.
• Our long-term goal is to develop practical and mechanistically informed strategies at the interface of organic synthesis, chemical biology, and materials science.

Current Members

Ph.D. Scholars

1. Mr. Vijayakumaran
2. Mr. Narayan
3. Ms. Riya
4. Mr. Winson
5. Ms. Anasuya

M.Sc. Students

1. Ms. Raqueal
2. Mr. Aditya
3. Mr. Adith
4. Mr. Gulshan

Alumni

Ph.D. Scholars

1. Dr. Subhashini
2. Dr. Pradeep
3. Dr. Anwesha
4. Dr. Arpita
5. Dr. Debashruthi
6. Dr. Thirupathi
7. Dr. Manojkumar

Postdoctoral Fellows

1. Dr. Pooja
2. Dr. Padmaja
3. Dr. Ramana
4. Dr. Kanchithalaivan

Master’s Students

1. Ms. Heena
2. Mr. Tanmay
3. Mr. Amogh
4. Mr. Joseph
5. Ms. Vaidehi
6. Mr. Jinan
7. Mr. Gracely
8. Ms. Suchismita
9. Mr. Vibhu
10. Mr. Badal
11. Ms. Gitanjali
12. Ms. Nayanthara
13. Ms. Shikta
14. Ms. Keerthana
15. Mr. J. Siddharth
16. Ms. Pratibha
17. Mr. Kabir
18. Ms. Shubhashree
19. Ms. Chudamani
20. Ms. Sheetal
21. Ms. Anamika
22. Ms. Bishwaprava
23. Ms. Blessy
24. Ms. Nidhi
25. Mr. Sourish
26. Mr. Nagsen
27. Ms. Adyasha
28. Mr. Sahil
29. Ms. Pragyanditi
30. Ms. Sayani

Core Courses

• C102 Chemistry II
• C203 Reaction Mechanisms in Organic Chemistry
• C204 Reagents in Organic Syntheses
• C301 Physical Organic Chemistry
• C403 Chemistry of Heterocycles and Natural Products 

Elective Courses

• C353 Classics in Molecules
• C555 Principles of Drug Action
• C565 Advanced Organic Chemistry
• C570 Advanced Heterocyclic Chemistry
• C572 Frontiers in Organic Synthesis 

Lab Courses

• C142 Chemistry Lab II
• C244 Biomolecular Chemistry Lab 
• C341 Organic Chemistry Lab I
• C344 Organic Chemistry Lab II

Major Academic and Institutional Responsibilities at NISER

• Infrastructure Development: Nodal Officer for design and installation of laboratory and office furniture in the new NISER campus.
• Academic Governance: Chairperson UGCI, Convener UGCS, and Member, Academic Council.
• National Examination Duties: NEST Coordinator and Member, NEST Question Paper Setting Committee.
• Student Welfare: Girls’ Hostel Warden / Residential Warden.
• Research Facility Management: In-charge of HPLC and GC-MS facilities.
• Academic Events: Convener, JNOST; Coordinator, RSC Workshop.
• Institutional Committees: Member, Internal Complaints Committee; Seminar In-charge for undergraduate students.