NISER

Experience:

Postdoc fellow, Department of Chemical Biology, OHSU, USA (2024 - 2025)

Advisor: Prof. James Frank

Simons postdoc fellow, Department of Biological Engineering, MIT, USA (2021 - 2024)

Advisor: Prof. Alan P. Jasanoff

Education: 

Ph.D. in Chemistry, University of Texas at Austin, USA (2015 - 2021)

Advisor: Prof. Jonathan L. Sessler

Dissertation Title: “Au(I) bis-N-heterocyclic Carbenes as Anti-cancer Therapeutics: Post-synthetic Modification Strategies and Immunogenic Cell Death

M.Sc. in Chemistry, Indian Institute of Technology Kanpur, India (2013 - 2015)

B.Sc. in Chemistry, RKMRC Narendrapur, India (2010 - 2013)

•  McGovern Travel and Tech Award at MIT, USA                                                                              2024

 Awarded by the McGovern Institute 

•  NIH travel award at World Molecular Imaging Congress, Prague                                            2023

 Awarded by World Molecular Imaging Society

• Simons Postdoctoral Fellowship at MIT, USA                                                                          2021- 2023

Awarded by Simons Center for Social Brain on autism research

• Indian Academy of Science Summer Research Fellowship                                                         2014 

Awarded by Indian Academy of Science 

• Dr. P. C. Rakshit Award at RKMRC Narendrapur                                                                           2013

Highest honor in Chemistry for overall academic excellence during undergraduate studies

• Dr. D. K. Mitra Memorial Prize at RKMRC Narendrapur                                                                2013

Highest grade in Chemistry at the undergraduate level

• INSPIRE Fellowship                                                                                                                      2010 – 2015

Awarded by Department of Science & Technology, Govt. of India 

• Sen, S.; Dawson, M.; Thiabaud, G. D.; Fayer, I.; Jasanoff, A. A Molecular Probe for Detecting Cholinesterase Activity in MRI. Proc. Natl. Acad. Sci. U. S. A. 2025 (Just accepted). 

• Levine, M.⁺; Sen, S.⁺; Maier, E.; Sessler, J.L..; Arambula, J. F. Long-Lived Immunogenic Cell Death Induced by A Water-Soluble Redox Active Au(I) Bis-N-Heterocyclic Carbene. J. Am. Chem. Soc. 2025 (Just accepted). [⁺Equal author contribution]

• Phi Van, V. D.; Sen, S.; Jasanoff, A.P. A different interpretation of the DIANA fMRI signal. Sci Adv 2024, 10 (13), 2034.

• Thiabaud, G. D.; Schwalm, M.; Sen, S.; Barandov, A.; Simon, J.; Harvey, P.; Spanoudaki, V. C.; Müller, P.; Sessler, J. L.; Jasanoff, A. P. A Texaphyrin-Based Calcium Sensor for Multimodal Imaging. ACS Sens 2023, 8 (10), 3855–3861.

• Sen, S.; Karoscik, K.; Maier, E.; Arambula, J. F. Immunogenic Cell Death-Inducing Metal Complexes: From the Benchtop to the Clinic. Curr. Opin. Chem. Biol. 2023, 73, 102277. [Corresponding author]

• Sen, S.⁺; Ishiwari, F.⁺; Kaur, R.⁺; Ishida, M.; Ray, D.; Kikuchi, K.; Mori, T.; Bähring, S.; Lynch, V. M.; Saeki, A.; Guldi, D. M.; Sessler, J. L.; Jana, A. Supramolecular Recognition within a Nanosized “Buckytrap” That Exhibits Substantial Photoconductivity. J. Am. Chem. Soc. 2023, 145 (2), 1031–1039. [⁺Equal author contribution]

• Sen, S.; Won, M.; Levine, M. S.; Noh, Y.; Sedgwick, A. C.; Kim, J. S.; Sessler, J. L.; Arambula, J. F. Metal-Based Anticancer Agents as Immunogenic Cell Death Inducers: The Past, Present, and Future. Chem. Soc. Rev. 2022, 51 (4), 1212–1233.

• Hu, X. Le; Sedgwick, A. C.; Mangel, D. N.; Shang, Y.; Steinbrueck, A.; Yan, K. C.; Zhu, L.; Snelson, D. W.; Sen, S.; Chau, C. V.; Juarez, G.; Lynch, V. M.; He, X. P.; Sessler, J. L. Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox. J. Am. Chem. Soc. 2022, 144 (16), 7382–7390.

• Chau, C. V.; Sen, S.; Sedgwick, A. C.; Gale, P. A.; Pantos, G. D.; Kim, S. K.; Park, J. S.; Tomat, E.; Arambula, J. F.; Gorden, A. E. V.; Furuta, H. Solving World Problems with Pyrrole: 65th Birthday Tribute to Prof. Jonathan L. Sessler. Chem 2022, 8 (3), 587–598.

• Xu, Y.; Wang, Y.; An, J.; Sedgwick, A. C.; Li, M.; Xie, J.; Hu, W.; Kang, J.; Sen, S.; Steinbrueck, A.; et al. 2D-Ultrathin MXene/DOXjade Platform for Iron Chelation Chemo-Photothermal Therapy. Bioact. Mater. 2021, 14, 76–85.

• Chen, J.⁺; Sedgwick, A. C.⁺; Sen, S.⁺; Ren, Y.; Sun, Q.; Chau, C.; Arambula, J. F.; Sarma, T.; Song, L.; Sessler, J. L.; Liu, C. Expanded Porphyrins: Functional Photoacoustic Imaging Agents That Operate in the NIR-II Region. Chem. Sci. 2021, 12 (29), 9916–9921. [⁺Equal author contribution]

• Sen, S.; Perrin, M. W.; Sedgwick, A. C.; Lynch, V. M.; Sessler, J. L.; Arambula, J. F. Covalent and Non-Covalent Albumin Binding of Au(I) Bis-NHCs via Post-Synthetic Amide Modification. Chem. Sci. 2021, 12 (21), 7547–7553.

• Steinbrueck, A.; Sedgwick, A. C.; Hwang, S.-M.; Sen, S.; Zhao, M. Y.; Huang, D.-Y.; Knoll, D. M.; Wang, Y.-Y.; Sessler, J. L. A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe³⁺. Chemosensors 2021, 9 (4), 68.

• Steinbrueck, A.; Sedgwick, A. C.; Han, H.; Zhao, M. Y.; Sen, S.; Huang, D.; Zang, Y.; Li, J.; He, X.; Sessler, J. L. In Vitro Studies of Deferasirox Derivatives as Potential Organelle-Targeting Traceable Anti-Cancer Therapeutics. Chem. Commun. 2021, 57 (46), 5678–5681.

• Sen, S.; Hufnagel, S.; Maier, E.; Aguilar, I.; Jayaraman. S.; DeVore, J. E.; Lynch, V. M.; Arumugam, K.; Cui, Z.; Sessler, J. L.; Arambula, J. F. Rationally Designed Redox-active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer. J. Am. Chem. Soc. 2020, 142 (49), 20536–20541.

• He, T.; Sedgwick, A. C.; Han, H.; Sen, S; Chen, G.; Zhang, Y.; Sessler, J. L.; James, T. D.; Li, J.; He, X.P. Fluorescent probes for the imaging of lipid droplets in live cells. Coord. Chem. Rev. 2021, 427, 213577.

• Kaur, R⁺.; Sen, S⁺.; Larsen, M. C.⁺; Tavares, L.; Kjelstrup-Hansen, J.; Ishida, M.; Zieleniewska, A.; Lynch, V. M.; Bähring, S.; Guldi, D. M.; Sessler, J. L. Jana, A. Semiconducting Supramolecular Organic Frameworks Assembled from a NIR Fluorescent Macrocyclic Probe and Fullerenes. J. Am. Chem. Soc. 2020, 142 (26), 11497–11505 (cover article) [⁺Equal author contribution] 

• Sen, S.; Perrin, M. W.; Sedgwick, A. C.; Dunsky, E. Y.; Lynch, V. M.; He, X.; Sessler, J. L.; Arambula, J. F. Toward Multifunctional Anticancer Therapeutics: Post-Synthetic Carbonate Functionalisation of Asymmetric Au(I) Bis-N-Heterocyclic Carbenes. Chem. Commun. 2020, 56 (57), 7877-7880.

• Williams, G. T.⁺; Sedgwick, A. C.⁺; Sen, S.⁺; Gwynne, L.; Gardiner, J. E.; Brewster, J. T.; Hiscock, J. R.; James, T. D.; Jenkins, A. T. A.; Sessler, J. L.  Boronate Ester Cross-Linked PVA Hydrogels for the Capture and H₂O₂-Mediated Release of Active Fluorophores. Chem. Commun. 2020, 56 (41), 5516–5519. [⁺Equal author contribution]

• Wang, F.; Sen, S.; Chen, C.; Bähring, S.; Lei, C.; Duan, Z.; Zhang, Z.; Sessler, J. L.; Jana, A. Self-Assembled Cagelike Receptor That Binds Biologically Relevant Dicarboxylic Acids via Proton-Coupled Anion Recognition.J. Am. Chem. Soc. 2020, 142 (4), 1987–1994.

• Thiabaud, G.; He, G.; Sen, S.; Shelton, K. A.; Baze, W. B.; Segura, L.; Alaniz, J.; MacIas, R. M.; Lyness, G.; Watts, A. B.; et al. Oxaliplatin Pt(IV) Prodrugs Conjugated to Gadoliniumtexaphyrin as Potential Antitumor Agents. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (13), 7021–7029.

• Sen, S.; Li, Y.; Lynch, V.; Arumugam, K.; Sessler, J. L.; Arambula, J. F. Expanding the Biological Utility of Bis-NHC Gold(I) Complexes through Post Synthetic Carbamate Conjugation. Chem. Commun. 2019, 55 (71), 10627–10630.

• Thiabaud, G.; Harden-Bull, L.; Ghang, Y. J.; Sen, S.; Chi, X.; Bachman, J. L.; Lynch, V. M.; Siddik, Z. H.; Sessler, J. L. Platinum(IV)-Ferrocene Conjugates and Their Cyclodextrin Host-Guest Complexes. Inorg. Chem.2019, 58 (12), 7886–7894.

• Sarma, T.; Kim, G.; Sen, S.; Cha, W. Y.; Duan, Z.; Moore, M. D.; Lynch, V. M.; Zhang, Z.; Kim, D.; Sessler, J. L. Proton-Coupled Redox Switching in an Annulated π-Extended Core-Modified Octaphyrin. J. Am. Chem. Soc. 2018, 140 (38), 12111–12119.