NISER

• Post Doctoral Fellow, Department of Immunology, University of Connecticut Health Center, USA : 2006-2008
• Post Doctoral Fellow, Department of Medicine, University of Connecticut Health Center, USA : 2003-2006 
• Ph.D from Department of Immunology, Indian Institute of Chemical Biology, Jadavpur University, Kolkata, India, 2003
• M.Sc in Zoology, University of Calcutta, Kolkata, India, 1998

Cellular Immunology: Infection Immunity, Cancer Immunology, Inflammation and Immune regulation

Recognition and Award:

• Recipient of Sudev Bhusan Ghosh Young Scientist Award by Zoological society, Kolkata, India, in 2002.
• Guest Editorial member (2013-2014) : Journal of Immunology Research, Hindawi Publishing Corporation.
• Guest Associate Editor in Frontiers in Immunology for T Cell Biology: Research Topic “Toll Like Receptor Response in Cell Mediated Immunity”  2021 
• "Rapid Grant for Young Investigators" by DBT, Ministry of Science and Technology, India, 2010.
• Received "Letter of appreciation" from Director, NISER for excellence in teaching in Advanced Immunology course at School of Biological Sciences, NISER

Life membership:

Society of Biological Chemist (SBC), India

Indian Society of Cell Biology

Indian Immunology Society

Indian Science Congress Association (ISCA)

Indian Virological Society (IVS)

Selected Publications:

• Khamaru S, Mukherjee T, Tung KS, Kumar PS, Bandyopadhyay S, Mahish C, Chattopadhyay S, Chattopadhyay S*. Chikungunya virus infection inhibits B16 melanoma-induced immunosuppression of T cells and macrophages mediated by interleukin 10. Microb Pathog. 2024 Oct 16;197:107022. doi: 10.1016/j.micpath.2024.107022. (* Corresponding author)
• Mukherjee T,  Tung KS, Jena P, Goswami C, Chattopadhyay S*. Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells. Immunol Invest. 2024 Apr 7:1-18. (*Corresponding author)
• Mahish, C., De, S., Chatterjee, S., Ghosh, S., Keshry, S. S., Mukherjee, T., Khamaru, S., Tung, K. S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S*. (2023). TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages. Frontiers in Immunology, 14, 1139808. https://doi.org/10.3389/fimmu.2023.1139808 (*Corresponding author)
• Chatterjee S, Kumar S, Mamidi P, Datey  A, Sengupta S, Mahish C, Laha E, De S, Keshry Supriya S, Nayak TK, Ghosh S, Singh S, Subudhi B B, Chattopadhyay S, and Chattopadhyay S. (2022) DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication. Journal of Virology 0, e01334-01322.
• Kumar PS, Radhakrishnan A, Mukherjee T, Khamaru S, Chattopadhyay S, & Chattopadhyay S*. (2022). Understanding the role of Ca2+ via transient receptor potential (TRP) channel in viral infection: Implications in developing future antiviral strategies. Virus Research, 323, 198992 (*Corresponding author). 
• Kumar PS, Mukherjee T, Khamaru S, Radhakrishnan A, Kishore DJN, Chawla S, Sahoo SS, Chattopadhyay S*. Elevation of TRPV1 expression on T-cells during experimental immunosuppression. Journal of Biosciences 2022, 47(3):42.(*Corresponding Author)
• De S, Ghosh S, Keshry Supriya S, Mahish C, Mohapatra C, Guru A, Mamidi P, Datey A, Pani Sweta S, Vasudevan D, Beuria Kant T, Chattopadhyay S, Subudhi Bhusan B, Chattopadhyay S. MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo. Antimicrobial Agents and Chemotherapy 2022, 0(0):e00463-00422. 
• De S, Mamidi P, Ghosh S, Keshry Supriya S, Mahish C, Pani Sweta S, Laha E, Ray A, Datey A, Chatterjee S, Singh S, Mukherjee T, Khamaru S, Chattopadhyay S*, Subudhi Bhusan B*, Chattopadhyay S*. Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways. Antimicrobial Agents and Chemotherapy 2022, 66(1):e01489-01421. (*Corresponding author)
• Subudhi BB, Chattopadhyay S & Chattopadhyay S. Targeting host factors of virus-induced inflammation: a strategy for tackling future epidemics by RNA
  viruses. Editorial, 10 Feb 2022. https://doi.org/10.2217/fvl-2021-0218. Future Virology, 2022
• Mamidi P, Nayak TK, Kumar A, Kumar S, Chatterjee S, De S, Datey A, Ghosh S, Keshry Supriya S, Singh S, Laha E, Ray A, Chattopadhyay S, Chattopadhyay S. MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway. PLoS Pathogens 2021, Nov 15;17(11): e1009667. 
• Kumar PS, Nayak TK, Mahish C, Sahoo SS, Radhakrishnan A, De S, Datey A, Sahu RP, Goswami C, Chattopadhyay S, Chattopadhyay S*.  Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages. Archieves of Virology. 2021 Jan;166(1):139-155. (*Corresponding author)  
• Sahoo SS, Majhi RK, Tiwari A, Acharya T, Kumar PS, Saha S, Kumar A, Goswami C*, Chattopadhyay S*. Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions.  Bioscience Reports. 2019 Sep 20;39(9). pii: BSR20191437. doi: 10.1042/BSR20191437. Print 2019 Sep 30 (*Corresponding author)
• Nayak TK, Mamidi P, Sahoo SS, Kumar PS, Mahish C, Chatterjee S, Subudhi BB, Chattopadhyay S and Chattopadhyay S * . P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages. Frontiers in Immunology, 2019 April 12. https ://doi.org/10.3389/fimmu.2019.0078610:786. (*Corresponding author)
• Sahoo SS, Pratheek BM, Meena VS, Nayak TK, Kumar SP, Bandyopadhyay S, Maiti PK, Chattopadhyay S*. VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responses. Scientific Reports 2018, 8: 7118 (*Corresponding author)
• Nayak TK, Mamidi  P, Kumar A, Singh LPK, Sahoo SS, Chattopadhyay S, Chattopadhyay S*. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. Viruses 2017, 9, 3; doi:10.3390/v9010003(* one of the corresponding authors)
• Majhi R, Sahoo S, Yadav J, Pratheek BM, Chattopadhyay S*, Goswami C*. Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Their Implications in Immune Regulation. FEBS J. 2015 Jul;282(14):2661-81. doi: 10.1111/febs.13306. (*Corresponding authors)
• Karimi S, Chattopadhyay S*, Chakraborty NG*. Manipulation of Regulatory T Cells and Antigen Specific CTL-based Tumor Immunotherapy.  Immunology. 2015 Feb;144(2):186-96 (*Corresponding authors)
• Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S*. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8+ T cell response and advancement of epitope based immunotherapy for CHIKV infection. Infection, Genetics and Evolution. 2015, 31:  118–126 (* Corresponding author)
• Rath S, Das L, Kokate SB, Pratheek BM, Chattopadhyay S, Goswami C, Chattopadhyay R, Crowe SE, Bhattacharyya A. Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. FASEB J. 2015  29, 796-806
• Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Basu S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S*, Kar S, Maiti PM. Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol. Int. 2014 Oct;38(10):1118-31 (*Corresponding author)
• Das I, Basantray I, Mamidi P, Nayak TK, Pratheek BM, Chattopadhyay S, Chattopadhyay S. Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLoS One. 2014 Jun 24;9(6):e100531
• Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Umarani Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. Journal of Virological Methods 2014, 199: 86– 94.
• Kumari J, Selvan SR, Becart S, Chattopadhyay S, Dalmo RA. Special Issue: Cell-mediated Immunity and Vaccines. Journal of Immunology Research, 2014; 2014:632632. (Editorial member)
• Pratheek BM, Saha S, Maiti PK, Chattopadhyay S, Chattopadhyay S*. Immune Regulation and Evasion of Mammalian Host Cell Immunity During Viral Infection. Indian Journal of Virology 2013 Jun; 24(1):1-15. (*Corresponding author)
• Chattopadhyay S*, Pal S, Pratheek BM, Meena VM, Singh S, Maiti PK. "Toll" Extending Its Gate from Drosophila Development to T Cell Response: Implication in Innate Immunity, Adaptive Immunity and Immunotherapy. Immunotherapy Insights 2011, 2: 1-14. (*Corresponding author)
• Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O' Rourke J, Flavell RA, and Clark RB. T cell sensitivity to TGF- β is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the Anterior Chamber. Int Immunol. 2009, 21:567-74.
• Chattopadhyay S, O'Rourke J and Cone RE. Implication for the CD94/NKG2A-Qa-1 System in the Generation and Function of Ocular-induced Splenic CD8+ Regulatory T cells. Int Immunol. 2008,  20:509-516
• Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y and O' Rourke J. The suppression of hypersensitivity by ocular–induced CD8+ T cells requires compatibility in the Qa-1 haplotype. Immunol Cell Biol. 2009 87:241-248.
• Chattopadhyay S, Mehrotra  S, Chhabra A, Hegde U, Mukherji B and Chakraborty NG. Effect of CD4+CD25+ and CD4+CD25- T Regulatory Cells on the Generation of Cytolytic T Cell Response to a Self but Human Tumor-Associated Epitope In Vitro.  Journal of Immunology, 2006, 176: 984- 990.
• Chattopadhyay S, Chakraborty NG, Mukherji B. Regulatory T cells and tumor immunity. Cancer Immunol Immunother. 2005, 54: 1153- 1161.
• Chattopadhyay S and. Chakraborty N. G. Continuous Presence of TH1 Conditions is Necessary for Longer Lasting Tumor-specific CTL Activity in Stimulation Cultures with PBL. Hum Immunol. 2005, 66: 884- 891.

(* Corresponding author)

Cellular and Immunological investigation towards altered host cell responses

The fundamental consequences of cellular responses associated to altered physiological processes during infection, cancer and/or tumor progression, inflammation and immunogenic responses in various cases of altered host cell functions and phenotypes are the prime interest of our ongoing research.

We have been working in the field of host cell responses and cellular immunology with special interest of ongoing immune-regulatory responses, cellular function and phenotypes associated to Cell mediated immunity (CMI) of T cells and accessory antigen presenting cells. Currently, we have major interest groups within NISER and also with external collaboration, where we are investigating functional expression of Toll like receptor (TLR) and Transient Receptor Potential Vanilloid (TRPV) Channels in cell mediated immunity (CMI), analyzing cellular and immunological response(s) of host cells during experimental Chikungunya virus (CHIKV) infection along with anti-cancer immunity as major projects.

In brief, our research focuses to dissect out the important roles of cellular and immunological aspects to decipher the cellular pathways, strategies associated to altered host cell responses for an ongoing infection, tumor progression, inflammation-immunity and immuno-regulatory processes associated to diseases biology in different contexts of cellular responses. Research with cell lines, primary cells, animal model and also with the human blood samples from normal donors and patients with due consents and National guide lines are the prime components for such experimental studies. Such understanding will be helpful towards designing immuno-therapeutic strategies to control various diseases.

Current PhD students:

Ms. Somlata Khamaru

Ms. Kshyama Subhadarsini Tung 

Mr. Partha Sarthathi Jena

Mr. Agniv Chakraborty

Former PhD students:

Dr. Tapas K. Nayak

Dr. Subhransu S. Sahoo

Dr. P. Sanjai Kumar

Dr. Chandan Mahish

Dr. Tathagata Mukherjee

Courses taught in NISER :
Animal Physiology; Cell Biology; Cancer Biology; Immunology, Advanced Immunology; Immune regulation and Infection immunity, Science of Life

Advisor: NISER Art club, NISER Staff Gymkhana

Member: PGCSB (SBS NISER)

Faculty In charge: Flow Cytometry Facility SBS NISER

Research Guidance: PhD students and MSc project students in SBS NISER

Teaching: Immunology Theory course, Immunology Lab course, Advanced Immunology Theory course, Integrated PhD students lab course in SBS NISER

Associate Editor: Frontiers in Immunology

Review Editor: Frontiers in Immunology

Review Editor: Frontiers in Cellular and Infection Microbiology