NISER

EDUCATION:

September 2017-July 2021- Postdoctoral research associate (Neuroscience)- Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California-92037, USA.

August 2016- August 2017– Postdoctoral associate (Neuroscience)- Neurodegenerative disease center, Scintillon Institute, San Diego, California- 92121, USA.

August 2008 - January 2016- PhD (Neuroscience)- Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012, India.

August 2006 - July 2008- M.Sc (Biophysics, Molecular biology and Genetics) – University college of Science and Technology, Kolkata- 700009, India.

August 2003 - July 2006 – B.Sc (Zoology) – Presidency College, Kolkata- 700073, India.

 

Neuroscience, Stem Cell Biology, Neurological disorders, Patch Clamp Electrophysiology, Ion channel Biology

Name of Award 

Awarding Agency 

Investigator-Initiated Research Proposals for Small Extramural Grants 

Start-up Research Grant (SRG)

List of Publications

Google scholar link- https://scholar.google.com/citations?user=xsEnuCEAAAAJ&hl=en

1. Ghatak S.^#, and Sikdar, S.K^#. Prolonged Exposure to Lactate causes TREK1 Channel Clustering in Rat Hippocampal Astrocytes. Neurosci Lett. (DOI 10.1016/j.neulet.2023). ^# Corresponding author. IF: 3.046.
2. Ghatak S., Nakamura T., Lipton S.A. Aberrant Protein S-Nitrosylation Contributes to Hyperexcitability-Induced Synaptic Damage in Alzheimer's Disease: Mechanistic Insights and Potential Therapies. Front. Neural Circuits, 2023 (DOI: 10.3389/fncir.2023.1099467), IF: 3.342.
3. Oh C., Nakamura T., Beutler N., Zhang X., Pina-Crespo J., Talantova M., Ghatak S., Trudler D., Carnevale L.N., McKercher S.R., Bakowski M.A., Diedrich J., Roberts A.J., Woods A.K., Chi V., Gupta A.K., Rosenfeld M.A., Kearns F.L., Casalino L., Shaabani N., Liu H., Wilson I.A., Amaro R.E., Burton D.R., Yates J.R., Becker C., Rogers T.F., Chatterjee A.K., Lipton S.A. Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection. Nat. Chem. Biol., 2022 (DOI: 10.1038/s41589-022-01149-6),IF: 16.290
4. Trudler D.*, Ghatak S.*, Lipton S.A.  Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases., Int. J. Mol. Sci., 2021 (DOI: 10.3390/ijms22158196) IF: 5.923 *equal contribution.
5. Pirie E., Oh C., Zhang X., Han X., Cieplak P., Scott H., Deal A., Ghatak S., Martinez F, Yeo G., Yates J., Nakamura T., and Lipton S. A. S-Nitrosylated TDP-43 triggers aggregation and neurotoxicity in hiPS cell-based models of ALS/FTD. PNAS, 2021 (DOI: 10.1073/pnas.2021368118) IF: 11.2.
6. Trudler D., Sanz-Blanco S., Eisele Y.S., Ghatak S., Akhtar M.W., Bodhinathan K., Piña-Crespo J., Talantova M., Kelly J.W., Lipton S.A. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. J. Neurosci., 2020 (DOI: 10.1523/JNEUROSCI.1871-20.2020) IF: 6.167.
7. Trudler D.*, Ghatak S.*, Parker J., Talantova M., Grabauskas T., Noveral S. M., Teranaka M., Luevanos M., Dolatabadi N., Bakker C., Lopez K., Sultan A., Chan A., Choi Y., Kawaguchi R., Schork N., Stankiewicz P., Bassets I. G., Kozbial P., Rosenfeld M. G., Nakanishi N., Geschwind D. H., Chan S. F., Ambasudhan R., Lipton. S.A. Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC neurons and cerebral organoids. bioArxiv2020 (DOI: 10.1101/2020.11.19.387639) *equal contribution.
8. Ghatak S., Dolatabadi N., Gao R., Trudler D., Wu Y., Scott H., Sultan A., Ambasudhan R., Nakamura T., Masliah E. Talantova M., Voytek B., Lipton S.A. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Mol. Psychiatry. 2020, (DOI: 10.1038/s41380-020-0776-7). Press release in Scripps Research news and events (https://www.scripps.edu/news-and-events/press-room/2020/20200529-lipton-alzheimer.html), IF: 15.992. 
9. Ghatak S., Talantova M., Mckercher S., Lipton S.A. Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases. Annu. Rev. Pharmacol. Toxicol. 2020 (DOI: 10.1146/annurev-pharmtox-032320-015420), IF: 13.82.
10. Ghatak S., Trudler D., Dolatabadi N. and Lipton S.A. hiPSC maintenance and differentiation. Bio-protocol. 2020 (bio-protocol.org/prep323).
11. Ghatak S*., Dolatabadi N*., Trudler D., Zhang X., Wu Y., Mohata M., Ambasudhan R., Talantova M., Lipton S.A. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control. eLife. 2019 (DOI:10.7554/eLife.50333), press release in Scripps Research news and events (https://www.scripps.edu/news-and-events/press-room/2019/20191212-lipton-alzheimers.html), *equal contribution, IF: 8.14.
12. Metri V., Ghatak S., Raha S., and Sikdar, S.K. Patch Clamp Data Driven Stochastic Modeling and Simulation of hTREK1 Potassium Ion Channel Gating. Chem. Phys. 2018 (DOI: 10.1016/j.chemphys.2018.07.030) IF: 2.348.
13. Ghatak S*., Trudler D*., Dolatabadi N., Ambasudhan R. Parkinson’s disease: what the model systems have taught us so far. J. Genet. 2018 (DOI: 10.1007/s12041-018-0960-6). *equal contribution, IF: 1.508.
14. Banerjee A.*, Ghatak S.*, and Sikdar, S.K. L-Lactate mediates neuroprotection against ischaemia
by increasing expression of TREK1 channels in rat hippocampal astrocytes in vitro.
J. Neurochem. 2016 (DOI: 10.1111/ jnc.13638), Cover page, *equal contribution, IF: 5.372.
15. Ghatak S., and Sikdar, S.K. Lactate modulates the intracellular pH sensitivity of human TREK1 channels. Pflugers Arch. 2016 (DOI: 10.1007/s00424-016-1795-8), IF: 3.657.
16.  Ghatak S.*, Banerjee A*. and Sikdar, S.K. Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain. J Physiol. 2015 (DOI: 10.1113/JP270706). *equal contribution, IF: 5.182.

Our research focusses on-
1. Elucidating pathophysiological mechanisms of neurological disorders focusing on ion channels.
2. Creating novel brain models using human induced pluripotent stem cells (hiPSCs) from patients
to study neurological disorders.
3. Translating novel mechanisms to develop therapy against neurological diseases.

List of Publications
Google scholar link- https://scholar.google.com/citations?user=xsEnuCEAAAAJ&hl=en

Courses taught-

B402/ B851/ BL660- Developmental Biology

B456/BL656- Advanced Neurobiology

B141- Biology Laboratory- I

B142- Biology Laboratory -II