Rudresh Acharya's Lab
Research Laboratory for Macromolecular Crystallography and Protein design
Publications
[# corresponding author]
2025
- 21. Nilima Mahapatra, Pranjal Mahanta, Shubhant Pandey,and Rudresh Acharya#, Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal-Sensing Sensor HistidineKinase ZraS, Proteins: Structure, Function, and Bioinformatics, 2025, 0:1–16 (https://doi.org/10.1002/prot.26819)
2024
- 20. Smitha Mohanlal#, Diprupa Saha, Shubhant Pandey, Rudresh Acharya# and Nagendra K. Sharma# Synthesis of R-GABA Derivatives via Pd(II) Catalyzed Enantioselective C(sp3)-H Arylation and Virtual Validation with GABAB1 Receptor for Potential leads, Chemistry An Asian Journal, 2024, (doi:10.1002/asia.202400064)
2023
- 19. Shubhant Pandey, Bryan W. Berger#, and Rudresh Acharya#, Structural Analyses of Substrate−pH Activity Pairing Observed across Diverse Polysaccharide Lyases, Biochemistry, 2023, 62(18), 2775-2790 (doi:10.1021/acs.biochem.3c00321)
2022
- 18. Prerana Dash and Rudresh Acharya#, Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase, ACS Central Science, 2022, 8(7), 933-947
2021
- 17. Shubant Pandey, Pranjal Mahanta, Bryan W. Berger#, Rudresh Acharya# , Structural insights into the mechanism of pH-selective substrate specificity of the polysaccharide lyase Smlt1473, Journal of Biological Chemistry, 2021, 297,101014 (PMID: 34358563, DOI: 10.1016/j.jbc.2021.101014)
- 16. Thota Peddarao, Ashim Baishya, Nabin Sarkar, Rudresh Acharya , Sharanappa Nembenna, Conjugated Bis-Guanidines (CBGs) as β-Diketimine Analogues: Synthesis, Characterization of CBGs/Their Lithium Salts and CBG Li Catalyzed Addition of B−H and TMSCN to Carbonyls Eur. J. Inorg. Chem., 2021, 2021(21), 2034–2046.
2017
- 15. Barsha Tripathy, Rudresh Acharya#, Production of Computationally Designed Small Soluble- and Membrane-Proteins: Cloning, Expression, and Purification, Methods Mol Bioli (Springer Nature). 2017, 1529:95-106.
- 14. V. Rao Mundlapati, Dipak Kumar Sahoo, Sanat Ghosh, Umesh Kumar Purame, Shubhant Pandey, Rudresh Acharya , Nitish Pal, Prince Tiwari, and Himansu S. Biswal, Spectroscopic Evidences for Strong Hydrogen Bonds with Selenomethionine in Proteins, J. Phys. Chem. Lett. , 2017 , 8 (4), 794–800.
2016
- 13. Kook-Han Kim, Dong-Kyun Ko, Yong-Tae Kim, Nam Hyeong Kim, Jaydeep Paul, Shao-Qing Zhang, Christopher B. Murray, Rudresh Acharya# , William F. DeGrado#, Yong Ho Kim# & Gevorg Grigoryan#, Protein-directed self-assembly of a fullerene crystal, Nature Communications , 2016 , 7:11429. (# corresponding author)
2014
- 12. Nathan H. Joh, Tuo Wang, Manasi P. Bhate, Rudresh Acharya , Yibing Wu, Michael Grabe, Mei Hong, Gevorg Grigoryan, and William F. DeGrado De novo design of a transmembrane Zn2+-transporting four-helix bundle Science , 2014 346(6216):1425-1588
2012
- 11. Christopher Lanci, Christopher M. MacDermaid, Seung-gu Kang, Rudresh Acharya , Benjamin North, Xi Yang, William F. Degrado, Jeffery G. Saven. Computational design of a protein crystal Proc. Natl. Acad. Sci. USA , 2012 109(19):7304-7309
2011
- 10. Gevorg Grigoryan*, Yong Ho Kim*, Rudresh Acharya , Kevin Axelrod, Rishabh M. Jain, Lauren Willis, Marija Drndic, James M. Kikkawa, William F. DeGrado Computational design of virus-like protein assemblies on carbon nanotube surfaces Science , 2011 332(6033):1071-1076. *co-first authors
2010
- 9. Rudresh Acharya* , Vincenzo Carnevale*, Giacomo Fiorin*, Benjamin G. Levine*, Alexei L. Polishchuk*, Victoria Balannik, Ilan Samish, Robert A. Lamb, Lawrence, H. Pinto, William F. DeGrado, Michael L. Klein. Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus Proc. Natl. Acad. Sci. USA , 2010 107(34):15075-15080. *co-first authors
2008
- 8. Amanda L. Stouffer *, Rudresh Acharya * , David Salom *, Anna S. Levine, Luigi Di Costanzo, Cinque S. Soto, Valentina Tereshko, Vikas Nanda, Steven Stayrook, William F. DeGrado. Structural basis for the function and inhibition of an influenza virus proton channel Nature , 2008 451(7178):596-599. *co-first authors
- 7. Madhvi Gupta, Rudresh Acharya , Aseem Mishra, Suryanarayanarao Ramakumar, Faizan Ahmed, Virander S. Chauhan. Dehydrophenylalanine (ΔPhe) as a β breaker: Extended structure terminated by a ΔPhe-induced turn in the pentapeptide Boc-Phe1-Ala2-Ile3-ΔPhe4-Ala5-OMe. ChemBioChem , 2008 9(9):1375-1378.
2007
- 6. Rudresh Acharya , Madhvi Gupta, Suryanarayanarao Ramakumar, Udupi A. Ramagopal, Virander S. Chauhan. Observation of glycine zipper and unanticipated occurrence of ambidextrous helices in the crystal structure of a chiral undecapeptide. BMC Structural Biology , 2007 , 7(1):51.
2005
- 5. Rudresh , Madhvi Gupta, Suryanarayanarao Ramakumar, Virander S. Chauhan. Helix packing motif common to the crystal structures of two undecapeptides containing dehydrophenylalanine residues: Implications for the de novo design of helical bundle super secondary structural modules. Biopolymers (Peptide Science), 2005 80(5): 617-627.
- 4. Suryanarayanarao Ramakumar, Rudresh , Udupi A. Ramagopal, Madhvi Gupta, Virander S. Chauhan. Glycine zipper motif in the association of helices in a designed peptide Acta Cryst., 2005 A61: C273.
2004
- 3. Rudresh , Suryanarayanarao Ramakumar, Udupi A. Ramagopal, Yoshihito Inai, Suchi Goel, Dinakar Sahal, Virander S. Chauhan. De novo design and characterization of a helical hairpin eicosapeptide; emergence of an anion receptor in the linker region. Structure , 2004 12(3):389-396.
2002
- 2. Rudresh Acharya , Udupi A. Ramagopal, Suryanarayanarao Ramakumar, Dinkar Sahal, Virander S. Chauhan. Role of weak interactions and flexible tetra-glycine linker in a de novo designed helical hairpin Eicosapeptide. Acta Cryst. 2002 A58: (Supplement), C122.
- 1. Rudresh , Rinku Jain, Vardhan Dani, Ashima Mitra, Sarika Srivastava, Siddhartha P. Sarma, Raghavan Varadarajan, Suryanarayanarao Ramakumar. Structural consequences of replacement of an alpha-helical Pro residue in Escherichia coli thioredoxin. Protein Eng., 2002 15 (8): 627-633.